Rani Mukherjee comes from a film industry family background. She is the daughter of Ram Mukherjee, director of Leader , starring Dilip Kumar and Vaijanthymala and Hum Hindustani. Her mother, Krishna Mukherjee, used to be a playback singer. Her cousin, Kajol, is a famous Bollywood actress.

Born on 21 March 1978, this light-eyed actress with a husky voice has a mass appeal. She is known to be a good-natured and lively person.

She has boldly tried a variety of roles in the span of a five-year film career. A series of unsuccessful films like Baadal and Had Kar Di Aapne did not dampen her spirits. She always looks ahead and keeps a positive attitude.

Her debut film, Raja Ki Ayegi Baraat, was made in 1996, but she actually became well-known for her film, Ghulam. The song 'Aati Kya Khandala" from this movie became famous. She is screen confident and comfortable working with top producers and directors. She has acted with all the top-class actors and has worked hard to make a place for herself on top.

She got the award for Best Supporting Actress for her performance in the film Kuch Kuch Hota Hai.

• Karan Johar's Kabhi Alvida Na Kehna Amitabh Bachchan, Shahrukh Khan, Urmila Matondkar, Preity Zinta, Abhishek Bachchan and Rani Mukherjee.
• Mani Ratnam's The Mahabharata starring Aamir Khan, Kajol, Shahrukh Khan and Rani Mukherjee. Music by AR Rehman.
• Ravi Chopra's Babul with Amitabh Bachchan, Hema Malini and Salman Khan.
• She is going to be play the lead role in Mira Nair's next film a screen adaptation of Pulitzer prize winner Jhumpa Lahiri’s 'The Namesake'.

Rani Mukherji won the award for Best Supporting Actress for her performance in the film Veer-Zaara at the International Indian Film Academy Awards on 11 Jun 2005.

Rani Mukherjee is number 10 on the Top Ten Filmfare Power List, conducted for Filmfare by AC Nielsen ORG-Marg. Rani is the only woman on the list.

Rani has been signed up for commercials of brands such as Fanta, Munch and Dabur.

• 12 Aug, 2005 Ketan Mehta's Mangal Pandey / The Rising historical on the mutiny of 1857, starring Aamir Khan and Rani Mukerji.
• 17 June, 2005 Amol Palekar's Paheli is based on Vijayadan Detha's novel Dooriyan. Cast Rani Mukerji, Shah Rukh Khan, Juhi Chawla and Amitabh Bachchan.
• 27 May, 2005 Shaad Ali's Bunty Aur Babli with Amitabh Bachchan as a cop hunting for 2 lost characters in the jungle, Bunty (Abhishek Bachchan) and Babli (Rani).
• 4 Feb, 2005 Sanjay Leela Bhansali Black with Bachchan.
• 12 Nov 2004 Veer Zaara (Sharukh Khan, Preity Zinta, MAnoj Bajpai, Amitabh Bachchan)
• 2004 Hum Tum (Saif Ali Khan)
• 2004 Yuva (Abhishek Bachchan)
• 2003 LOC: Kargil (Ajay Devgan)
• 2003 Chalte Chalte (Shah Rukh Khan)
• 2003 Sathiya (Vivek Oberoi)
• 2002 Mujhse Dosti Karoge (Hiritik Roshan, Kareena Kapoor)
• 2002 Nayak (Anil Kumar)
• 2001 Dekha Jayega (Chandrachur Singh)
• 2001 Chori Chori Chupke Chupke (Salman Khan)
• 2001 Bas Itna sa Khawab Hai (Abhishek Bachchan)
• 2000 Yudh (Arbaaz Khan)
• 2000 Pyar Deewana Hota Hai (Govinda)
• 2000 Mulaqat (Akshay Kumar)
• 2000 Kahin Pyar Na Ho Jaye (Salman Khan, Jackie Shroff)
• 2000 HAr Dil Jo Pyar Karega (Salman Khan)
• 2000 Hey Ram (Kamal Hasan)
• 2000 Hadh Kar Di Aapne (Govinda)
• 2000 Chalo Ishq LAdayen (Govinda)
• 2000 Bichhoo (Bobby Deol)
• 2000 Baadal (Bobby Deol)
• 1999 Mann (Aamir Khan)
• 1999 Hello Brother (Salman Khan )
• 1998 Mehandi (Faraaz Khan)
• 1998 Kuch Kuch Hota Hai (Shah Rukh Khan and Kajol )
• 1998 Ghulam (Amir Khan)
• 1996 Raja Ki Ayegi Baraat

Some of her best performances were showcased in movies such as the following:

• Veer Zaara - Best Supporting Actress Award.
• Yuva - She won best supporting actress for 'Yuva' in the 50th Filmfare, Screen, Cinegoers, and Sports World awards (2004).
• Ghulam
• Nayak
• Kuch Kuch Hota Hai - Best supporting actress award.
• Chori Chori Chupke Chupke
• Nayak
• Saathiya

She got awards for Best Supporting Actress for her performances in the films Kuch Kuch Hota Hai and Veer-Zaara.